Antiphospholipid syndrome is a thrombotic disorder and the serologic marker of the syndrome is antiphospholipid antibody(lupus anticoagulant, anticardiolpin antibody, or both). In a 13-year-old girl who presented with dyspnea, pulmonary embolism
and
femoral vein thrombosis were demonstrated by lung scan and abdominal ultrasonography.
She had 3 out of 11 criteria for the diagnosis of SLE, such as thrombocytopenia, positive antinuclear antibody, low C3 and high anti-ds-ANA Ab, but did not meet whole criteria. And lupus anticoagulant was positive.
She was treated with anticoagulants(heparin and wafarin) and prednisolone. Antiphospholipid antibody(lupus anticoagulant and anticardiolipin antibody) should be checked in children with thrombosis occurring without a known predisposing cause.
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